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Fosamax What is Fosamax? Fosamax is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures. Fosamax is used in women to treat or prevent osteoporosis caused by menopause and in men and women to treat osteoporosis caused by taking steroids. Fosamax is also used to increase bone mass in men who have osteoporosis, and to treat Paget's disease of bone in men and women. Warnings You should not take Fosamax if you have problems with your esophagus, or low levels of calcium in your blood. Do not take Fosamax if you cannot sit upright or stand for at least 30 minutes after taking the medicine. Fosamax can cause serious problems in the stomach or esophagus. Stop using ...